Molecular imaging of ventricular remodeling
نویسندگان
چکیده
منابع مشابه
Magnetic resonance imaging to assess ventricular remodeling
Ventricular remodeling has a key role in the pathology of ventricular dysfunction. During the reaction to a myocardial insult, the ensuing genetic, structural, and biochemical changes will result in the deterioration of the functional ability of the heart in the long term. Non invasive imaging plays a central part in the diagnosis of heart failure, assessment of ventricular remodeling, prognosi...
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Despite advances in reperfusion therapy, acute coronary syndromes can still result in myocardial injury and subsequent myocardial infarction (MI). Molecular, cellular, and interstitial events antecedent to the acute MI culminate in deleterious changes in the size, shape, and function of the left ventricle (LV), collectively termed LV remodeling. Three distinct anatomic and physiologic LV region...
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BACKGROUND Matrix metalloproteinase (MMP) activation plays a key role in vascular remodeling. RP782 is a novel indium (111)In-labeled tracer with specificity for activated MMPs. We hypothesized that RP782 can detect injury-induced vascular remodeling in vivo. METHODS AND RESULTS Left common carotid artery injury was induced with a guidewire in apolipoprotein E(-/-) mice. Sham surgery was perf...
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Angiogenesis and vascular remodeling are involved in a wide array of cardiovascular diseases, from myocardial ischemia and peripheral arterial disease, to atherosclerosis and aortic aneurysm. Molecular imaging techniques to detect and quantify key molecular and cellular players in angiogenesis and vascular remodeling (e.g., vascular endothelial growth factor and its receptors, αvβ3 integrin, an...
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ژورنال
عنوان ژورنال: Journal of Nuclear Cardiology
سال: 2009
ISSN: 1071-3581,1532-6551
DOI: 10.1007/s12350-009-9078-9